Outer Retinal Necrosis Due to a Strain of Varicella-Zoster Virus Resistant to Acyclovir, Ganciclovir, and Sorivudine

Meningoradiculoneuritis due to acyclovir-resistant varicella-zoster virus in a patient with AIDS.

Colleagues—Varicella-zoster virus (VZV) has been recognized as one of the most frequent viral opportunistic infections in patients infected with the human immunodeficiency virus (HIV). The classic presentation of VZV infection in patients with AIDS is a multidermatomal zoster with or without dissemination. Persistent VZV infections with atypical cutaneous lesions have been recognized with incre...

Outer Retinal Necrosis Due to a Strain of Varicella- Zoster Virus Resistant to Acyclovir, Ganciclovir, and Sorivudine Theinhibitory activityof acycloviris basedon itsphosphorylation by theviralthymidine kinase(TK).AfterpatientswithAIDSreceive long-termtreatmentwith acyclovirfor the controlof infections with herpes zoster and herpes simplex viruses, resistant isolates

Theinhibitory activityof acycloviris basedon itsphosphorylation by theviralthymidine kinase(TK).AfterpatientswithAIDSreceive long-termtreatmentwith acyclovirfor the controlof infections with herpes zoster and herpes simplex viruses, resistant isolates may appear. Most of the resistant strains are either deficient in TK or inducea TK withan alteredsubstratespecificity [I, 2]. Foscarnethas a diff...

A Case of Severe Hepatitis due to Varicella Zoster

In vitro susceptibility of varicella-zoster virus to acyclovir.

The in vitro susceptibility of five strains of varicella-zoster virus to acyclovir was examined by the plaque-reduction method in human diploid lung cells. The 50% effective doses of acyclovir ranged from 2.06 microM to 6.28 microM in a 7-day assay, with a mean of 3.65 microM. Irreversible inhibition of plaque formtation was achieved by drug doses exceeding the 50% effective dose for plaque red...

Myelitis due to varicella-zoster virus in two patients with AIDS: successful treatment with acyclovir.

Only a few cases of varicella-zoster virus (VZV) myelitis have been described, and nearly all have been diagnosed post-mortem. There have been no reports in the literature of successful treatment of VZV myelitis with antiviral medications. We report on two patients with AIDS who had acute severe myelitis accompanied by herpes zoster. The presence of VZV DNA in cerebrospinal fluid (CSF) was docu...